Job Description

The peptide chemistry unit is seeking a talented peptide chemist with a strong background in peptide & macrocycle chemistry, as well as expertise in organic synthesis. The successful candidate will be passionate about conducting high-quality scientific research to advance internal and external peptide drug discovery programs. The candidate will be involved in the design of new molecules to progress structure-activity relationship studies and in the planning and execution of multi-step syntheses, purification, and analytical characterization of complex peptides to achieve agreed-upon objectives in a timely manner. The successful candidate will communicate effectively with internal and external collaborators and will work efficiently in a multi-disciplinary team environment.

Key responsibilities

Develop and execute synthetic strategies towards complex molecules using state-of-the-art synthetic methodologies.
Analyze and identify compounds using different purification and spectroscopic techniques.
Contribute to the design of peptides with improved potency and physiochemical properties to advance programs according to scientific strategies and goals within a project team setting.
Present data and reports on project status at internal and external meetings.
Conduct laboratory operations in a safe manner. Exhibit safety awareness and safe work practices; comply with all safety requirements according to Italian laws.

Competencies/skills

In/depth knowledge of peptide chemistry
Expertise in design and synthesis of complex peptides, including peptide conjugates, macrocycles, and small proteins
Mastery of use of laboratory equipment with a preference for knowledge on the use of peptide synthesizers
Design and execution of synthetic routes for the synthesis of amino acids and building blocks
Excellent knowledge of common purification techniques (HPLC, IEX, GPC) and analytical techniques (UPLC/HPLC and mass spectrometry)
Experience in the discovery of therapeutic peptides in an industrial environment will be considered a plus
Knowledge in structure elucidations of organic molecules by NMR and MS
Outstanding organizational skills.
Excellent communication skills, both verbal and written
Good knowledge of English is mandatory
Ability to productively work in teams

Qualifications:

Master of Science Degree (Laurea Magistrale) in Chemistry with 5 years of experience doing peptide chemistry in a pharmaceutical or biotech environment.
PhD in Chemistry with one or more relevant postdoctoral experiences or with experience in a pharmaceutical or biotech environment.

The position is based in Pomezia (RM).

During the job interview, we will evaluate each candidate’s experience, and the job offer will be commensurate.

We thank all applicants for their interest. Only candidates selected for interviews will be contacted.